CD86 and CSTA

		CD86	CSTA
Description		CD86 molecule	cystatin A
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Centriolar Satellite Extracellular Exosome	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Adaptive Immune Response Positive Regulation Of Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cell Population Proliferation CD40 Signaling Pathway T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Formation of the cornified envelope
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)	Apolipoprotein B levels ( 32203549) Calcium levels ( 25972035 29403010 20705733)
Interacting Genes		15 interacting genes: CD28 CD80 CSTA CTLA4 ECE2 FXR1 INHBA KPNA1 MARCHF8 MCM2 P4HA2 PARP1 TEX55 TRA2A TRH	13 interacting genes: CD86 CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17
Entrez ID		942	1475
HPRD ID		03011	01697
Ensembl ID		ENSG00000114013	ENSG00000121552
Uniprot IDs		A0A0X9R4E0 A8K632 P42081	P01040
PDB IDs		1I85 1NCN 5YXK	1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE
Enriched GO Terms of Interacting Partners?
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