ORMDL1 and CREB3L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ORMDL1	CREB3L1
Description		ORMDL sphingolipid biosynthesis regulator 1	cAMP responsive element binding protein 3 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane SPOTS Complex	Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Sphingolipid de novo biosynthesis	CREB3 factors activate genes
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Ferritin levels ( 25162662)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30578418)
Interacting Genes		37 interacting genes: APP AQP6 ARL13B ASGR2 COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 GPR152 HSD17B11 KCNK4 LMNA LNX1 MFSD14B PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35C2 STOM TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27	197 interacting genes: ADAM33 ADGRE2 ADIPOQ AGPAT3 AGPAT4 AGPAT5 ALG8 ANKRD46 AOC3 APOD AQP10 AQP2 ARV1 ASGR1 BET1 BMP10 BNIP3 BRICD5 C11orf24 C4orf3 C5 CCL4L2 CD53 CD72 CD99L2 CFHR5 CIAO2A CLN6 CMTM3 CMTM7 CNIH2 COL8A2 COMT COX20 CREB3 CREB3L3 CREM CSGALNACT2 CTSA CTXN3 CXCL16 CYB561D2 CYBC1 CYP4F2 DDIT3 DOLK EBP EMP3 ENTPD3 ERG28 ERMP1 FA2H FAM3C FAXDC2 FETUB FXYD3 FXYD6 GAST GIMAP1 GIMAP5 GOLT1B GOSR2 GPR151 GPR25 GPR37L1 HACD2 HIF1A IL1RL1 INSIG2 ITGAM JAGN1 KCNK1 LEPROTL1 LHFPL5 LPAR3 LTC4S MAL MAL2 MALL MAN2B2 MARCHF2 MFSD5 MGAM MGST2 MGST3 MMD2 MS4A1 MS4A13 NAPB NAT8 NEU1 NINJ1 NINJ2 NRM NSG1 OLFM4 OR10AG1 ORMDL1 ORMDL2 PAQR6 PEDS1-UBE2V1 PEX16 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 PLPP6 PLPPR2 PMP22 PRKAB2 PTPMT1 PTPN9 RFT1 RHBDD1 RHD RNASE10 RUNX1T1 RUSF1 SACM1L SCARF1 SCD SCGB1D1 SEC22A SEC22B SEC61G SEMA4G SFXN5 SLC13A2 SLC13A3 SLC16A13 SLC2A3 SLC30A8 SLC35A4 SLC35B1 SLC35B2 SLC35B4 SLC35C2 SLC39A2 SLC39A9 SLC52A1 SLC7A1 SMCO4 SMIM1 SPOCK1 SQLE STX3 STX7 STX8 SYNGR1 SYNJ2BP TECR TEX264 TFRC TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM11 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM50B TMEM86A TMIE TNF TNFRSF10C TNMD TRAM1L1 TSPAN18 TSPAN2 TSPO TSPO2 UBIAD1 UNC93B1 VAMP1 VAMP2 VEZT VKORC1 WFDC2 YIPF6 ZDHHC15 ZDHHC22 ZFPL1 ZNF408
Entrez ID		94101	90993
HPRD ID		15092	16751
Ensembl ID		ENSG00000128699	ENSG00000157613
Uniprot IDs		Q9P0S3	B2RA75 Q96BA8
PDB IDs
Enriched GO Terms of Interacting Partners?
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