NRXN1 and NLGN1

Number of citations of the paper that reports this interaction (PubMedID 12796785)
217

Data Source:
BioGRID (pull down, pull down, pull down)
HPRD (in vitro)

		NRXN1	NLGN1
Description		neurexin 1	neuroligin 1
Image
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Nuclear Membrane Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Postsynaptic Density Dendrite Filopodium Tip Synaptic Cleft Dendritic Spine Dendritic Shaft Receptor Complex Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Postsynapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Amyloid-beta Binding PDZ Domain Binding Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Neuron Cell-cell Adhesion Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Vocal Learning Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Vocalization Behavior Positive Regulation Of Synapse Maturation Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Excitatory Postsynaptic Potential	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Chemical Synaptic Transmission Nervous System Development Synapse Assembly Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Cytoskeletal Matrix Organization At Active Zone Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Neurexin Clustering Involved In Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Postsynaptic Specialization Assembly Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Presynapse Assembly Synaptic Membrane Adhesion Neuron Projection Arborization Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Localization To Synapse Positive Regulation Of Intracellular Signal Transduction Excitatory Synapse Assembly Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Nicotine dependence symptom count ( 25555482) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Recurrent major depressive disorder ( 34099189) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Smoking initiation ( 33082346) Systolic blood pressure ( 30224653 30578418) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32203549) Word spelling ( 30741946)	Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Frailty index ( 34431594) Hand grip strength ( 29691431) Major depressive disorder ( 20516156) Metabolite levels ( 23823483) Motion sickness ( 25628336) Periodontitis (DPAL) ( 24024966) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)
Interacting Genes		29 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A RTN4 SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	6 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3
Entrez ID		9378	22871
HPRD ID		11858	07195
Ensembl ID		ENSG00000179915	ENSG00000169760
Uniprot IDs		A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 E7ERL8 H0Y568 H7BYC7 P58400 Q9ULB1	Q8N2Q7
PDB IDs		3B3Q 5Z8Y 6NID	5OJ6 5OJK
Enriched GO Terms of Interacting Partners?
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