KIF3B and MAP3K11

Number of citations of the paper that reports this interaction (PubMedID 9427749)
71

Data Source:
BioGRID (two hybrid)

		KIF3B	MAP3K11
Description		kinesin family member 3B	mitogen-activated protein kinase kinase kinase 11
Image
GO Annotations	Cellular Component	Centrosome Cytosol Kinesin Complex Plus-end Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Membrane Kinesin II Complex Dendrite Midbody Dendrite Cytoplasm Dendritic Spine Extracellular Exosome Ciliary Tip Axon Cytoplasm	Centrosome Cytosol Microtubule Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Small GTPase Binding Intraciliary Transport Particle B Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Microtubule-based Movement Mitotic Spindle Organization Mitotic Centrosome Separation Determination Of Left/right Symmetry Anterograde Axonal Transport Vesicle-mediated Transport Positive Regulation Of Cytokinesis Opsin Transport Intraciliary Transport Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Mitotic Spindle Assembly Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants
Drugs			Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252)	Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: APP IFT20 KIF3A KIFAP3 LMO2 LMO4 MAP3K10 MAP3K11 NEDD4L PRC1 RAB4A SASH1	33 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 FKBP2 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 MYO7A NEIL1 PIN1 PNLIPRP2 RAC1 RHOG SH3RF1 STUB1 TIA1 TRAF6 TSGA10IP
Entrez ID		9371	4296
HPRD ID		04781	02502
Ensembl ID		ENSG00000101350	ENSG00000173327
Uniprot IDs		O15066	A0A024R5E6 Q16584
PDB IDs		3B6U	5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?