SLIT2 and CSDE1

		SLIT2	CSDE1
Description		slit guidance ligand 2	cold shock domain containing E1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Membrane Extracellular Exosome	P-body Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex
	Molecular Function	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Roundabout Binding	RNA Binding Protein Binding RNA Stem-loop Binding
	Biological Process	Ureteric Bud Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Adiponectin levels x Mediterranean diet adherence interaction ( 33562295) Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Early spontaneous preterm birth ( 31194736) Echocardiographic traits ( 17903301) Gestational age at birth (child effect) ( 31194736) HDL cholesterol levels in HIV infection ( 33109212) Pars orbitalis volume ( 31530798) QRS duration ( 27659466) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Autism ( 24189344)
Interacting Genes		11 interacting genes: CSDE1 GPC1 HOXA1 OGT PAX8 PDE4B ROBO1 ROBO2 SEL1L3 UBC ZCCHC4	23 interacting genes: C11orf68 CDC7 CTBS DOK1 DPYD ERBB2 FAM9B GCKR GCNT1 GFI1 HID1 HNRNPD IGFBP5 KCNMB4 PABPC1 PCSK7 SH3GLB1 SLIT2 SNRPB2 STT3A SYNCRIP WFS1 WNK1
Entrez ID		9353	7812
HPRD ID		04776	15949
Ensembl ID		ENSG00000145147	ENSG00000009307
Uniprot IDs		O94813	A0A024R0E2 A0A024R0K2 O75534
PDB IDs		2V70 2V9S 2V9T 2WFH	1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?
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