CNOT8 and CNOT6

Number of citations of the paper that reports this interaction (PubMedID 10637334)
66

Data Source:
HPRD (two hybrid)

		CNOT8	CNOT6
Description		CCR4-NOT transcription complex subunit 8	CCR4-NOT transcription complex subunit 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Nuclear Receptor Coactivator Activity Metal Ion Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of Transcription, DNA-templated Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Ovarian cancer ( 30557369) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	4 interacting genes: CNOT4 CNOT7 CNOT8 PABPC1
Entrez ID		9337	57472
HPRD ID		07225	12341
Ensembl ID		ENSG00000155508	ENSG00000113300
Uniprot IDs		B7Z9U0 Q9UFF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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