GCM2 and TOX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GCM2	TOX3
Description		glial cells missing transcription factor 2	TOX high mobility group box family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Chromatin DNA Binding Protein Homodimerization Activity Phosphoprotein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cellular Calcium Ion Homeostasis Multicellular Organism Development Cellular Phosphate Ion Homeostasis Gliogenesis Positive Regulation Of Transcription By RNA Polymerase II Parathyroid Gland Development	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (grey matter) ( 28763065) BRCA1 mutation in breast cancer ( 33597508) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 21263130 20872241 24143190 25327703 29059683 23535729 23535733 27117709 20585626 31757997 20453838 25956309 19330030) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (male) ( 23001122) Breast cancer in BRCA2 mutation carriers ( 23544012) Chronotype ( 30696823) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 27479909) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Parkinson's disease ( 28892059) Polycystic ovary syndrome ( 22885925 30566500) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Restless legs syndrome ( 29029846 21779176)
Interacting Genes		35 interacting genes: CD83 CEACAM6 CRX DOK3 ECM1 FHL3 GPSM1 GSC2 HOXA1 HSF2BP HSFY1 HSFY2 JMJD7 KRTAP6-2 KRTAP7-1 KRTAP8-1 LASP1 LHX3 MEOX2 MYOZ3 PAX6 PAX8 PLEKHG4 POU6F2 RBPMS RUSC1 SSBP1 TBX19 TOX3 TRAF1 USP54 WWOX YPEL3 ZMIZ2 ZNF34	12 interacting genes: DUSP21 FHL2 GCM2 IST1 KRTAP9-3 KRTAP9-8 NUP62CL PIN1 POM121 SEZ6L2 TLE5 TSTD2
Entrez ID		9247	27324
HPRD ID		04758	19073
Ensembl ID		ENSG00000124827	ENSG00000103460
Uniprot IDs		O75603	O15405
PDB IDs
Enriched GO Terms of Interacting Partners?
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