LRAT and HSD17B13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LRAT	HSD17B13
Description		lecithin retinol acyltransferase	hydroxysteroid 17-beta dehydrogenase 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Retinoic Acid Binding Protein Binding O-palmitoyltransferase Activity Acyltransferase Activity Retinol Binding Phosphatidylcholine-retinol O-acyltransferase Activity Lecithin:11-cis Retinol Acyltransferase Activity	Molecular_function Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Retinoid Metabolic Process Vitamin A Metabolic Process Visual Perception Response To Bacterium Positive Regulation Of Lipid Transport Response To Retinoic Acid Response To Vitamin A Retinol Metabolic Process Cellular Response To Leukemia Inhibitory Factor	Positive Regulation Of Lipid Biosynthetic Process
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism and transport	Lipid particle organization
Drugs		Vitamin A
Diseases
GWAS		Activated partial thromboplastin time ( 29403010) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)
Interacting Genes		6 interacting genes: BLCAP HSD17B13 RBP1 RBP2 TMEM31 TMX2	118 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LPCAT2 LRAT MARCHF5 MFSD5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM140 TMEM14C TMEM167B TMEM19 TMEM203 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAPA VAPB YIPF2 YIPF4
Entrez ID		9227	345275
HPRD ID		05332	18023
Ensembl ID		ENSG00000121207	ENSG00000170509
Uniprot IDs		O95237	Q7Z5P4
PDB IDs
Enriched GO Terms of Interacting Partners?
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