VAPA and RMDN2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		VAPA	RMDN2
Description		VAMP associated protein A	regulator of microtubule dynamics 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Spindle Microtubule Integral Component Of Membrane Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Cadherin Binding Protein Heterodimerization Activity	Protein Binding Microtubule Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Cell Death Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)	Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Cutaneous malignant melanoma ( 26237428) Eosinophil counts ( 32888494) Melanoma ( 28212542)
Interacting Genes		37 interacting genes: ADGRG7 ADRB2 APOD AQP6 CACNG1 CD79A CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 LEPROTL1 NSF OPRM1 OSBP PGRMC2 RETREG3 RMDN2 SCN3B SEC11C SIK1 SLC16A7 SLC35B1 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 VAMP1 VAMP2 ZBTB22	14 interacting genes: AGTRAP CMTM5 DIABLO HSD17B11 LMNA RDH10 RTN3 SAR1A STX1A THAP4 TNFRSF10D VAPA VAPB VEZT
Entrez ID		9218	151393
HPRD ID		09299	08741
Ensembl ID		ENSG00000101558	ENSG00000115841
Uniprot IDs		Q9P0L0	A0A0C4DFM4 Q96LZ7
PDB IDs		2RR3 6TQR
Enriched GO Terms of Interacting Partners?
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