CD247 and LY6E

Number of citations of the paper that reports this interaction (PubMedID 9575182)
10

Data Source:
HPRD (in vivo, in vitro)

		CD247	LY6E
Description		CD247 molecule	lymphocyte antigen 6 family member E
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Extracellular Region Plasma Membrane Anchored Component Of Membrane Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding	Protein Binding Acetylcholine Receptor Inhibitor Activity Acetylcholine Receptor Binding
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	In Utero Embryonic Development Cell Surface Receptor Signaling Pathway Adrenal Gland Development Organ Growth Norepinephrine Metabolic Process Negative Regulation Of Viral Entry Into Host Cell Epinephrine Secretion Ventricular Cardiac Muscle Tissue Morphogenesis Acetylcholine Receptor Signaling Pathway Negative Regulation Of Signaling Receptor Activity
Pathways			Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Muromonab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	14 interacting genes: AKR1B1 CD247 EIF3H FCGR2B GLI4 GML GPAA1 HSF1 JRK MFSD6 PIP TMEM140 TMEM19 TRARG1
Entrez ID		919	4061
HPRD ID		01729	03227
Ensembl ID		ENSG00000198821	ENSG00000160932
Uniprot IDs		P20963	Q16553
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR
Enriched GO Terms of Interacting Partners?
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