ALKBH8 and MFAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALKBH8	MFAP1
Description		alkB homolog 8, tRNA methyltransferase	microfibril associated protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Microfibril Extracellular Region Nucleus Nucleoplasm U2-type Spliceosomal Complex Centrosome U2-type Precatalytic Spliceosome
	Molecular Function	TRNA Binding Iron Ion Binding Protein Binding Zinc Ion Binding TRNA (uracil) Methyltransferase Activity 2-oxoglutarate-dependent Dioxygenase Activity TRNA (carboxymethyluridine(34)-5-O)-methyltransferase Activity	RNA Binding Protein Binding
	Biological Process	TRNA Wobble Uridine Modification Cellular Response To DNA Damage Stimulus TRNA Methylation	MRNA Splicing, Via Spliceosome
Pathways		tRNA modification in the nucleus and cytosol	Molecules associated with elastic fibres
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Large artery stroke ( 24262325)	Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
Interacting Genes		3 interacting genes: APP MFAP1 PICK1	89 interacting genes: ALKBH8 AMOTL2 AP2M1 BEND7 BHLHB9 BICD2 CARD9 CCDC102B CCDC33 CCDC57 CDC14B CDCA7L CEP55 CEP57L1 CEP70 CEP76 COG6 CSNK2A1 DHX38 DHX8 DNTTIP1 FAM9B FRA10AC1 FXR1 FXR2 GAS8 GKAP1 GOLGA2 GOLGA6L9 GRIPAP1 HMBOX1 HOMER3 HOOK2 HSF2BP HSPB1 IK KATNBL1 KIFC3 KLHL2 KRT40 L3MBTL3 LDOC1 LMNA LMNB2 LZTS1 MAD1L1 MCRS1 MID2 MIPOL1 MTUS2 NDC80 NGDN OGT OLIG3 PAX6 PHC2 PIBF1 PIH1D1 PLEKHF2 SNW1 SSX2IP STAC3 STX11 TADA2A TCP10L TEPSIN TFIP11 THAP1 TLE5 TRAF2 TRIM41 TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB1 ZBTB14 ZBTB8A ZFP1 ZFP41 ZFP64 ZNF398 ZNF41 ZNF558 ZNF620 ZNF71 ZNF76 ZRANB1
Entrez ID		91801	4236
HPRD ID		14287	02569
Ensembl ID		ENSG00000137760	ENSG00000140259
Uniprot IDs		Q96BT7	P55081
PDB IDs		2CQ2 3THP 3THT	5F5S 5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI
Enriched GO Terms of Interacting Partners?
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