PCSK7 and PABPC1

Number of citations of the paper that reports this interaction (PubMedID 11051545)
119

Data Source:
HPRD (in vivo)

		PCSK7	PABPC1
Description		proprotein convertase subtilisin/kexin type 7	poly(A) binding protein cytoplasmic 1
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Membrane Integral Component Of Golgi Membrane	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	RNA Binding MRNA 3'-UTR Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity
	Biological Process	Protein Processing Peptide Hormone Processing	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Polyadenylation Gene Silencing By RNA Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 31170924 24507774) Iron status biomarkers ( 21149283) Refractive error ( 32231278) Triglyceride levels ( 26763881) Triglycerides ( 24507774)	Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP TRIM54	56 interacting genes: ANAPC5 APBB1 ATP6V1C1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 DCAF13 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LINC01554 LRP12 LRP1B MAPKAPK2 MET MKRN1 NDRG1 ODF1 OGT PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCED1A PCSK7 PIN1 PITPNA PRMT6 PXN RACK1 RBM4 RIMS2 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG
Entrez ID		9159	26986
HPRD ID		05339	05247
Ensembl ID		ENSG00000160613	ENSG00000070756
Uniprot IDs		Q16549	A0A024R9C1 P11940
PDB IDs			1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS
Enriched GO Terms of Interacting Partners?
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