ARHGEF1 and CD44

Number of citations of the paper that reports this interaction (PubMedID 12748184)
87

Data Source:
HPRD (in vivo)

		ARHGEF1	CD44
Description		Rho guanine nucleotide exchange factor 1	CD44 molecule (Indian blood group)
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Degradation of the extracellular matrix Cell surface interactions at the vascular wall Integrin cell surface interactions Hyaluronan uptake and degradation Neutrophil degranulation Interferon gamma signaling
Drugs			Bivatuzumab Hyaluronic acid
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)	Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 27723757 22561518)
Interacting Genes		11 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4	70 interacting genes: ABCB5 AKT1 ANK1 ARHGEF1 ARHGEF12 ARNT BDNF CAT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK CSTF3 DMP1 DPT EGFR EPB41 EPHA2 ERBB2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK LMO2 MADCAM1 MAP2K3 MAP2K5 MAP3K13 MDM4 MET MMP1 MMP7 MMP9 MSN NF2 NONO PDGFRA PKN1 RAF1 RIMS2 SELE SPP1 SRC SRD5A1 SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL
Entrez ID		9138	960
HPRD ID		03511	00115
Ensembl ID		ENSG00000076928	ENSG00000026508
Uniprot IDs		A0A024R0R1 Q92888	P16070
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A	1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?
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