PRPF4 and SRSF1

Number of citations of the paper that reports this interaction (PubMedID 11418604)
27

Data Source:
HPRD (in vitro)

		PRPF4	SRSF1
Description		pre-mRNA processing factor 4	serine and arginine rich splicing factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP U2-type Precatalytic Spliceosome Spliceosomal SnRNP Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding U6 SnRNA Binding U4 SnRNA Binding	RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding DNA Topoisomerase Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing	Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing Positive Regulation Of RNA Splicing Oligodendrocyte Differentiation MRNA Transport Liver Regeneration
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs			Copper
Diseases
GWAS		White matter growth ( 29682794)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		9 interacting genes: APP ATP5MF CLK1 GPKOW PPIH SRSF1 TGFBR1 U2AF1 WBP4	42 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK6 CLK1 DANCR DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PPARG PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		9128	6426
HPRD ID		08479	02887
Ensembl ID		ENSG00000136875	ENSG00000136450
Uniprot IDs		O43172 Q5T1M7	Q07955 Q59FA2
PDB IDs		1MZW 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	1X4A 2M7S 2M8D 2O3D 3BEG 4C0O 6HPJ 7ABG
Enriched GO Terms of Interacting Partners?
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