PIP4P1 and EPN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PIP4P1	EPN2
Description		phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1	epsin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Late Endosome Membrane	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding
	Biological Process	Phospholipid Metabolic Process Response To Sterol Depletion Cholesterol Metabolic Process Lysosome Localization Phosphatidylinositol Dephosphorylation Proton-transporting V-type ATPase Complex Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of TORC1 Signaling	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Sprouting Angiogenesis
Pathways		PI5P Regulates TP53 Acetylation Synthesis of PIPs in the nucleus	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		4 interacting genes: EPN2 PLEKHB2 RILPL1 SLC10A6	40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG
Entrez ID		90809	22905
HPRD ID		12660	06271
Ensembl ID		ENSG00000165782	ENSG00000072134
Uniprot IDs		Q86T03	O95208
PDB IDs
Enriched GO Terms of Interacting Partners?
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