CCT6A and KDM5A

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		CCT6A	KDM5A
Description		chaperonin containing TCP1 subunit 6A	lysine demethylase 5A
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GO Annotations	Cellular Component	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Extracellular Exosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding WD40-repeat Domain Binding	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone H3-tri/di/monomethyl-lysine-4 Demethylase Activity Methylated Histone Binding Histone Binding Dioxygenase Activity
	Biological Process	Protein Folding Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Chromatin Remodeling Spermatogenesis Male Gonad Development Circadian Regulation Of Gene Expression Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Positive Regulation Of Transcription, DNA-templated Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Histone Deacetylase Activity
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle	HDMs demethylate histones
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 34021172) Macular telangiectasia type 2 ( 33654266) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Systolic blood pressure ( 30224653)	Body mass index ( 26426971) Pulse pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		16 interacting genes: DUX4 ERCC6 IMPA2 KDM5A LINC01554 MLX MYBPC2 OGT PARP4 PTEN SGCG SUMO2 SUMO4 SUPT16H TRIM31 TTN	12 interacting genes: CCT6A ESR1 H3-4 H3C15 LMO2 NR3C1 PKP2 RARA RB1 RBL1 TBP VDR
Entrez ID		908	5927
HPRD ID		00089	08915
Ensembl ID		ENSG00000146731	ENSG00000073614
Uniprot IDs		A0A024RDL1 P40227	P29375
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP	2JXJ 2KGG 2KGI 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T 6BGU 6BGV 6BGW 6BGX 6BGY 6BGZ 6BH0 6BH1 6BH2 6BH3 6BH4 6BH5 6DQ4 6DQ5 6DQ6 6DQ7 6DQ8 6DQ9 6DQA 6DQB 6DQC 6DQD 6DQE 6DQF 7KLO 7KLR
Enriched GO Terms of Interacting Partners?
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