OTULIN and SPATA2

Number of citations of the paper that reports this interaction (PubMedID 27545878)
47

Data Source:
BioGRID (unspecified method)

		OTULIN	SPATA2
Description		OTU deubiquitinase with linear linkage specificity	spermatogenesis associated 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Fibrillar Center Nucleoplasm Cytoplasm
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Spermatogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Protein K63-linked Deubiquitination Seminiferous Tubule Development Protein Linear Deubiquitination
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)	Coronary artery disease ( 29212778) Gut microbiota (beta diversity) ( 27723756) Psoriasis ( 20953189 25574825 18364390)
Interacting Genes		10 interacting genes: BCL10 DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239	22 interacting genes: ANKRD11 APP ATP6V1H C2CD6 CCDC102B CEP72 DUT EFHC1 GOLGA2 GPANK1 KAT5 KIFC3 LENG1 MAD1L1 OTULIN PTPN6 RNF31 TBC1D22B TNIP1 TRAF2 TRIM27 ZNF835
Entrez ID		90268	9825
HPRD ID		14266	09636
Ensembl ID		ENSG00000154124	ENSG00000158480
Uniprot IDs		Q96BN8	A8K0S9 B4DID4 Q9UM82
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK	5LJM 5LJN
Enriched GO Terms of Interacting Partners?
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