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WNT3A and LRP1
Number of citations of the paper that reports this interaction (PubMedID
14739301
)
48
Data Source:
HPRD
(in vitro, in vivo)
WNT3A
LRP1
Description
Wnt family member 3A
LDL receptor related protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Plasma Membrane
Cell Surface
Endocytic Vesicle Membrane
Early Endosome Membrane
Extracellular Exosome
Presynapse
Glutamatergic Synapse
Wnt-Frizzled-LRP5/6 Complex
Nucleus
Lysosomal Membrane
Early Endosome
Golgi Apparatus
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Basolateral Plasma Membrane
Clathrin-coated Vesicle
Dendrite
Endocytic Vesicle Membrane
Insulin-responsive Compartment
Neuronal Cell Body
Receptor Complex
Axonal Growth Cone
Apical Part Of Cell
Plasma Membrane Protein Complex
Molecular Function
Transcription Coactivator Activity
Signaling Receptor Binding
Frizzled Binding
Cytokine Activity
Protein Binding
Protein Domain Specific Binding
Co-receptor Binding
Receptor Ligand Activity
Amyloid-beta Binding
Protease Binding
RNA Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Calcium Ion Binding
Protein Binding
Coreceptor Activity
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Clathrin Heavy Chain Binding
Apolipoprotein Binding
Signaling Receptor Activity
Cargo Receptor Activity
Heparan Sulfate Proteoglycan Binding
Protein-containing Complex Binding
Lipoprotein Particle Receptor Binding
Biological Process
Osteoblast Differentiation
In Utero Embryonic Development
Positive Regulation Of Cytokine Production
Positive Regulation Of Protein Phosphorylation
Heart Looping
Positive Regulation Of Receptor Internalization
Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway
Axon Guidance
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
COP9 Signalosome Assembly
Positive Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Spinal Cord Association Neuron Differentiation
Hippocampus Development
Cell Proliferation In Forebrain
Wnt Signaling Pathway Involved In Forebrain Neuroblast Division
Dorsal/ventral Neural Tube Patterning
Hemopoiesis
Neuron Differentiation
Extracellular Matrix Organization
Mammary Gland Development
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein Binding
Positive Regulation Of Peptidyl-serine Phosphorylation
Cell Proliferation In Midbrain
Cellular Protein Localization
Skeletal Muscle Cell Differentiation
Post-anal Tail Morphogenesis
Synaptic Vesicle Recycling
Inner Ear Morphogenesis
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Fate Commitment
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Somatic Stem Cell Division
Positive Regulation Of Mesodermal Cell Fate Specification
Paraxial Mesodermal Cell Fate Commitment
Positive Regulation Of Skeletal Muscle Tissue Development
Positive Regulation Of Collateral Sprouting In Absence Of Injury
Negative Regulation Of Axon Extension Involved In Axon Guidance
Negative Regulation Of Neurogenesis
Modulation Of Chemical Synaptic Transmission
Regulation Of Synapse Organization
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Dermatome Development
Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
Secondary Palate Development
Regulation Of Microtubule Cytoskeleton Organization
Platelet Aggregation
Cellular Response To Retinoic Acid
Axis Elongation Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel
Presynapse Assembly
Postsynapse To Nucleus Signaling Pathway
Negative Regulation Of Neuron Death
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Dopaminergic Neuron Differentiation
Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Regulation Of Presynapse Assembly
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Hepatocyte Proliferation
Positive Regulation Of Cardiac Muscle Cell Differentiation
Retinoid Metabolic Process
Astrocyte Activation Involved In Immune Response
Lipid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis
Lysosomal Transport
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Aging
Cell Population Proliferation
Negative Regulation Of Gene Expression
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Cell Death
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Smooth Muscle Cell Migration
Cerebral Cortex Development
Negative Regulation Of Wnt Signaling Pathway
Receptor Internalization
Positive Regulation Of Protein Binding
Positive Regulation Of Lipid Transport
Regulation Of Cholesterol Transport
Regulation Of Phospholipase A2 Activity
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Aorta Morphogenesis
Lipoprotein Metabolic Process
Lipoprotein Transport
Apoptotic Cell Clearance
Negative Regulation Of Neuron Apoptotic Process
Cellular Lipid Catabolic Process
Transcytosis
Positive Regulation Of Endocytosis
Positive Regulation Of Axon Extension Involved In Regeneration
Positive Regulation Of Collateral Sprouting Of Injured Axon
Positive Regulation Of Phagocytosis
Negative Regulation Of Cytosolic Calcium Ion Concentration
Negative Regulation Of Focal Adhesion Assembly
Negative Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Chemoattraction Of Axon
Positive Regulation Of ERK1 And ERK2 Cascade
Amyloid-beta Clearance
Amyloid-beta Clearance By Transcytosis
Amyloid-beta Clearance By Cellular Catabolic Process
Transport Across Blood-brain Barrier
Positive Regulation Of Schwann Cell Migration
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cholesterol Import
Positive Regulation Of Transcytosis
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Metallopeptidase Activity
Positive Regulation Of Lysosomal Protein Catabolic Process
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways
TCF dependent signaling in response to WNT
TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
Signaling by RNF43 mutants
Scavenging of heme from plasma
Retinoid metabolism and transport
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Coagulation Factor IX (Recombinant)
Lanoteplase
Coagulation Factor IX Human
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Birth weight (
31043758
)
Diastolic blood pressure (
28135244
)
Height (
31562340
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Abdominal aortic aneurysm (
27899403
22055160
)
Adult asthma (
30787307
)
Asthma (
31959851
27182965
31619474
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
28552196
)
Cervical artery dissection (
25420145
)
Coronary artery disease (
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
28334899
)
Headache (
29397368
)
Height (
31562340
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (anilides) (
31015401
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
22683712
27182965
23793025
21666692
27322543
)
Migraine - clinic-based (
23793025
)
Migraine without aura (
23793025
27322543
)
Moyamoya disease (
29273593
)
Peak expiratory flow (
30804560
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Spontaneous coronary artery dissection (
32887874
32374345
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
25961943
20686565
)
Interacting Genes
11 interacting genes:
DLG1
DLG2
DLG4
FZD1
GPC3
LRP1
LRP6
PORCN
RYK
WNT1
WNT2
76 interacting genes:
A2M
ANAPC10
ANKS1B
APBA2
APBB1
APOE
APP
BACE1
BDNF
C3
C4BPA
CACNA1A
CALR
CANX
CAV1
CC2D1A
CCN2
CD82
CLU
CSRP2
CTSG
DAB1
DAB2
DLG4
EGFR
ELANE
F8
F9
FURIN
GIPC1
GTPBP1
GULP1
HNRNPDL
HSP90AA1
HSP90B1
ITGB1BP1
KAT5
LIPC
LPL
LRPAP1
LTF
MAPK8IP1
MAPK8IP2
MAPRE1
MDK
MMP13
MMP14
MMP15
MMP16
MMP17
MTDH
NAB2
NGF
NOS1AP
NTF3
NTF4
PDGFB
PID1
PIGA
PLAT
PLAUR
PMEL
PRKACA
PTPN11
RIC8B
SCN3A
SERPINA1
SERPINE1
SHC1
SKIL
SNRNP70
SNX17
SRC
SYNJ2BP
THBS1
WNT3A
Entrez ID
89780
4035
HPRD ID
05897
00138
Ensembl ID
ENSG00000154342
ENSG00000123384
Uniprot IDs
P56704
Q07954
Q59FG2
PDB IDs
1CR8
1D2L
1J8E
2FYJ
2FYL
2KNX
2KNY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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