EIF2B5 and EIF2S2

Number of citations of the paper that reports this interaction (PubMedID 10805739)
36

Data Source:
HPRD (in vitro)

		EIF2B5	EIF2S2
Description		eukaryotic translation initiation factor 2B subunit epsilon	eukaryotic translation initiation factor 2 subunit beta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Ovarian Follicle Development Translational Initiation Aging Response To Heat Response To Glucose Response To Lithium Ion Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translational Initiation Astrocyte Differentiation Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Male Gonad Development
Pathways		Recycling of eIF2:GDP	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494 27863252) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		12 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B STX11	27 interacting genes: AAR2 APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 KIZ NCK1 OGT PLEKHM1 PRKDC TLE1 TNFRSF25 TP53 UNC119 ZBTB16
Entrez ID		8893	8894
HPRD ID		04898	04882
Ensembl ID		ENSG00000145191	ENSG00000125977
Uniprot IDs		Q13144	P20042 Q6IBR8
PDB IDs		3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46	6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43
Enriched GO Terms of Interacting Partners?
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