MCM3AP and MCM3

Number of citations of the paper that reports this interaction (PubMedID 12226073)
22

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MCM3AP	MCM3
Description		minichromosome maintenance complex component 3 associated protein	minichromosome maintenance complex component 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Membrane Nuclear Pore Nuclear Basket Transcription Export Complex 2	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	Nucleic Acid Binding Chromatin Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity Histone Binding	DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	MRNA Export From Nucleus Protein Transport Somatic Hypermutation Of Immunoglobulin Genes Poly(A)+ MRNA Export From Nucleus Nucleosome Organization Histone H3 Acetylation	Double-strand Break Repair Via Break-induced Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494) Periodontitis ( 30218097) Testicular germ cell tumor ( 25877299 28604728 23666240)	Cryptococcosis in HIV infection ( 33269293)
Interacting Genes		19 interacting genes: APC CDC25A CDC42 CDC73 CLSTN1 CRMP1 ENY2 EP300 FAM118B MCM3 NUDT5 POLR2G RAC1 SMAD3 SMAD9 SUV39H2 TAF1D TMEM216 TSC22D1	37 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TFAP2B TRIM28 YWHAQ
Entrez ID		8888	4172
HPRD ID		04483	04072
Ensembl ID		ENSG00000160294	ENSG00000112118
Uniprot IDs		O60318	A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205
PDB IDs		4DHX	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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