FGF16 and MFHAS1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
16

Data Source:
BioGRID (pull down)

		FGF16	MFHAS1
Description		fibroblast growth factor 16	multifunctional ROCO family signaling regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Cytoplasm Mitochondrion Lysosome Cytoskeleton
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding GTP Binding Ubiquitin Protein Ligase Binding Protein Phosphatase 2A Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Temperature Stimulus Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Migration Regulation Of MAP Kinase Activity Positive Regulation Of Brown Fat Cell Proliferation Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Inflammatory Response Erythrocyte Differentiation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Dephosphorylation Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer
Drugs
Diseases
GWAS		Height ( 31562340)	Acne (severe) ( 24927181) Adventurousness ( 30643258) Age at first sexual intercourse ( 27089180) Aspartate aminotransferase levels ( 33547301) Bipolar disorder (early vs late onset) ( 34016946) Body shape index ( 34021172) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cooked vegetable consumption ( 32066663) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 29187730) Neuroticism ( 29255261) Processed meat consumption ( 32066663) Refractive error ( 32231278) Skin aging (microtopography measurement) ( 28502801) Systemic lupus erythematosus ( 28714469) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: APP CLP1 DVL3 HOOK2 INCA1 KRT31 MCC MFHAS1 PICK1 PTX3	88 interacting genes: ABLIM1 AGFG1 AHCYL1 AHDC1 ANKRD13A ANKRD13D ANKS4B APEX2 AURKB BAG2 CABP4 CALM1 CALML3 CALU CAPRIN1 CBLB CCDC149 CCDC43 CDC42EP3 CEBPZ CEP85 CETN3 CHGB CLK1 COPB2 CRTC2 CUEDC1 CYREN DDI1 DRC3 E2F4 EGLN2 ESRRG ETV5 FGF16 FGFR1 FOXN3 GAK GAS2L3 GPBP1L1 GSDMD GTSF1 HIC2 IFTAP KLHDC4 LIMA1 LIMK1 MAP3K4 MRGBP NEK1 NEK11 PDCL PGRMC2 PJA2 PMM1 POLA2 POLI PPARG PRKAG2 PSME3IP1 RASL11B RCN2 RHBDD1 ROR1 RPAP3 RTKN SELENOS SH2D2A SLC4A1AP SMTNL2 SNAI1 STK25 STN1 STUB1 SUPT4H1 TADA3 TAS2R60 TBC1D22B TOX2 TRAPPC2 TRIM22 TTC27 UBL7 VGLL4 VN1R1 WWTR1 ZFAND5 ZMYM5
Entrez ID		8823	9258
HPRD ID		04764	12010
Ensembl ID		ENSG00000196468	ENSG00000147324
Uniprot IDs		O43320	Q9Y4C4
PDB IDs
Enriched GO Terms of Interacting Partners?
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