DPM1 and DPM3

Number of citations of the paper that reports this interaction (PubMedID 10835346)
48

Data Source:
HPRD (in vivo)

		DPM1	DPM3
Description		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mannosyltransferase Complex Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Mannose Binding Alcohol Binding	Protein Binding Enzyme Activator Activity
	Biological Process	GPI Anchor Biosynthetic Process Dolichol Metabolic Process GDP-mannose Metabolic Process Protein Mannosylation Protein O-linked Mannosylation	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Regulation Of Protein Stability Protein Mannosylation Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		7 interacting genes: DPM2 DPM3 MEOX2 MTNR1A PTEN TDO2 ZBTB16	6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147
Entrez ID		8813	54344
HPRD ID		04613	16179
Ensembl ID		ENSG00000000419	ENSG00000179085
Uniprot IDs		A0A0S2Z4Y5 O60762 Q5QPK2	A0A140VJI4 Q86TM7 Q9P2X0
PDB IDs
Enriched GO Terms of Interacting Partners?
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