TNFRSF11A and TRAF5

Number of citations of the paper that reports this interaction (PubMedID 9774460)
119

Data Source:
HPRD (in vitro)

		TNFRSF11A	TRAF5
Description		TNF receptor superfamily member 11a	TNF receptor associated factor 5
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Signaling Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Positive Regulation Of Bone Resorption Lymph Node Development Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Multinuclear Osteoclast Differentiation	Apoptotic Process Signal Transduction Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade MRNA Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Interleukin-17-mediated Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		ENMD-1198
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576 29875488) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Myasthenia gravis ( 25643325) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100) Serum alkaline phosphatase levels ( 33547301 29403010 33339817) Vitiligo ( 27723757)	Household income (MTAG) ( 31844048)
Interacting Genes		14 interacting genes: CBL CBLB ETFA FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6	66 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 CDC37 CIB3 COG7 COMMD3 DGKH ENOX2 FAM9A FBXO28 GAS8 GOLGA2 GORASP2 HOMER1 HSD17B10 HSF2BP LMO4 LNX1 LTBR MAP3K14 MAP3K5 MDM2 MEOX2 NMI NTAQ1 NUMBL ODF2 PIAS2 PIBF1 PICK1 PSMA1 RAD23A RIPK1 RIPK2 RNF111 RNF4 SDCBP SEC13 SERPINB9 SUMO1 TBK1 TDP2 THAP1 THAP7 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 YPEL5 ZFAND6 ZNF655
Entrez ID		8792	7188
HPRD ID		04609	03834
Ensembl ID		ENSG00000141655	ENSG00000082512
Uniprot IDs		Q9Y6Q6	O00463
PDB IDs		1LB5	7L3L
Enriched GO Terms of Interacting Partners?
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