ADAM9 and SCN8A

		ADAM9	SCN8A
Description		ADAM metallopeptidase domain 9	sodium voltage-gated channel alpha subunit 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Focal Adhesion Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Exosome	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Axon Initial Segment
	Molecular Function	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding ATP Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Keratinocyte Differentiation Positive Regulation Of Cell Migration Membrane Protein Intracellular Domain Proteolysis Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Response To Laminar Fluid Shear Stress Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide Response To Antineoplastic Agent	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Membrane Depolarization During Action Potential
Pathways		Collagen degradation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		INCB7839	Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Basophil count ( 32888494)	Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)
Interacting Genes		13 interacting genes: ADAM32 HTRA4 ITGA3 ITGA6 ITGAV MAD2L2 PLEKHA7 PRKCD SCN8A SH3D19 SH3GLB1 SNX9 TNF	6 interacting genes: ADAM9 FGF13 FGF14 GNAO1 MAPK14 OS9
Entrez ID		8754	6334
HPRD ID		04091	09006
Ensembl ID		ENSG00000168615	ENSG00000196876
Uniprot IDs		Q13443	Q6B4S4 Q9UQD0
PDB IDs		1M1V
Enriched GO Terms of Interacting Partners?
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