HRK and BCL2A1

Number of citations of the paper that reports this interaction (PubMedID 15694340)
743

Data Source:
HPRD (in vitro)

		HRK	BCL2A1
Description		harakiri, BCL2 interacting protein	BCL2 related protein A1
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GO Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane	Mitochondrial Outer Membrane
	Molecular Function	Protein Binding	Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cerebral Cortex Development Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Hippocampal volume ( 28098162 22504421) Presubiculum volume ( 30279459) Presubiculum volume (corrected for total hippocampal volume) ( 30279459) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)
Interacting Genes		9 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP CBR1 MCL1 MED1	18 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK CT45A1 FAM9B GRB2 GSK3B HRK NR4A1 PMAIP1 SLC9A3R1
Entrez ID		8739	597
HPRD ID		04581	03034
Ensembl ID		ENSG00000135116	ENSG00000140379
Uniprot IDs		O00198	Q16548
PDB IDs		2L58 2L5B 6XY4	2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP 6VO4
Enriched GO Terms of Interacting Partners?
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