CRADD and BBS5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CRADD	BBS5
Description		CASP2 and RIPK1 domain containing adaptor with death domain	Bardet-Biedl syndrome 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584 33713608) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Iris heterochromicity ( 30895295)
Interacting Genes		22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1	13 interacting genes: CFAP210 COTL1 CRADD CTSK EIF4EBP3 HRH1 KLC3 KLHL23 KLHL41 ORM2 PRDM2 SLC6A15 UBR3
Entrez ID		8738	129880
HPRD ID		04584	10353
Ensembl ID		ENSG00000169372	ENSG00000163093
Uniprot IDs		B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43	A0A0S2Z626 Q8N3I7
PDB IDs		2O71 2OF5 3CRD	6XTB
Enriched GO Terms of Interacting Partners?
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