TNFRSF25 and EIF2S2

		TNFRSF25	EIF2S2
Description		TNF receptor superfamily member 25	eukaryotic translation initiation factor 2 subunit beta
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GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Signaling Receptor Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Male Gonad Development
Pathways		TNFs bind their physiological receptors	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS			Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		12 interacting genes: BAG4 DAP3 EIF2S2 MAPK1 NCOA7 NPPB SLC2A5 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	27 interacting genes: AAR2 APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 KIZ NCK1 OGT PLEKHM1 PRKDC TLE1 TNFRSF25 TP53 UNC119 ZBTB16
Entrez ID		8718	8894
HPRD ID		04532	04882
Ensembl ID		ENSG00000215788	ENSG00000125977
Uniprot IDs		Q93038	P20042 Q6IBR8
PDB IDs		5YGP 5YGS	6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43
Enriched GO Terms of Interacting Partners?
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