NOL4 and SUZ12

		NOL4	SUZ12
Description		nucleolar protein 4	SUZ12 polycomb repressive complex 2 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex
	Molecular Function	RNA Binding	Transcription Corepressor Binding Protein Binding Enzyme Activator Activity Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding
	Biological Process		Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Catalytic Activity Histone H3-K27 Trimethylation
Pathways			PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis
Drugs
Diseases
GWAS		Breast size ( 22747683) Chronotype ( 30696823) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Neurociticism ( 29500382) Response to citalopram treatment ( 19846067) Schizophrenia ( 30285260) Smoking initiation ( 33082346) Urate levels in overweight individuals ( 25811787)	High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		17 interacting genes: AKT1 C1QTNF2 CHMP2A CTBP1 CTBP2 FAM9B MAGEA11 MAPK6 MEOX2 P4HB PRMT1 SKA3 SNAPC5 SUZ12 SYCE1L TEX9 ZNF383	25 interacting genes: AEBP2 ARHGAP5 BCL11A CDK19 CDK5R1 CDK8 CREB1 EZH2 H1-1 H3-4 KLRC1 LATS2 MED17 MED6 NOL4 NR1D1 PAXIP1 PJA1 PLA2G2A PRDM14 RBBP4 SLC2A2 TBC1D29P UBE2I WDR77
Entrez ID		8715	23512
HPRD ID		04657	06949
Ensembl ID		ENSG00000101746	ENSG00000178691
Uniprot IDs		B3KRF4 B4DLW2 O94818	J3QQW9 Q15022
PDB IDs			4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP
Enriched GO Terms of Interacting Partners?
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