SLC4A4 and SLC4A7

Number of citations of the paper that reports this interaction (PubMedID 10600945)
8

Data Source:
HPRD (in vivo)

		SLC4A4	SLC4A7
Description		solute carrier family 4 member 4	solute carrier family 4 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Spanning Component Of Plasma Membrane Extracellular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Stereocilium
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity Symporter Activity Transmembrane Transporter Activity Identical Protein Binding	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity Transmembrane Transporter Activity
	Biological Process	Sodium Ion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Ion Homeostasis Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport Transport Across Blood-brain Barrier	Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Ion Homeostasis Regulation Of Intracellular PH Transmembrane Transport Auditory Receptor Cell Development Anion Transmembrane Transport
Pathways		Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	Bicarbonate transporters RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 30578418) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549 28869591) Mosquito bite size ( 28199695) QT interval ( 24952745 29874175) Refractive error ( 32231278)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Blood pressure ( 21909110) Breast cancer ( 21263130 29059683 23535729 20453838 19330027) Breast cancer (early onset) ( 24493630) Diastolic blood pressure ( 27841878 21909115 28739976 27618447 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 25249183) Lymphocyte counts ( 32888494) Macular telangiectasia type 2 ( 33654266) Macular thickness ( 30535121) Mean arterial pressure ( 29403010 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 29403010 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28135244 21909115 29403010 28739976 27618452 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Urinary potassium excretion ( 31409800) Urinary potassium to creatinine ratio ( 30910378) Uterine fibroids ( 30194396)
Interacting Genes		5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2	8 interacting genes: CFTR CIAO1 DLG4 KRTAP4-5 MTNR1B SLC4A4 SLC9A3R1 YWHAB
Entrez ID		8671	9497
HPRD ID		04516	04521
Ensembl ID		ENSG00000080493	ENSG00000033867
Uniprot IDs		A5JJ20 Q9Y6R1	B5M450 E9PFN4 Q9Y6M7
PDB IDs		6CAA
Enriched GO Terms of Interacting Partners?
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