IRS2 and PROZ

		IRS2	PROZ
Description		insulin receptor substrate 2	protein Z, vitamin K dependent plasma glycoprotein
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Protein-containing Complex	Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Extracellular Exosome
	Molecular Function	Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Brain Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Lipid Homeostasis Cellular Response To Glucose Stimulus	Proteolysis Blood Coagulation
Pathways		PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling	Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Aspartate aminotransferase levels ( 34315874) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Factor VII ( 17903294) Food allergy (parent-of-origin effect) ( 29489655) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		50 interacting genes: ATP2A1 ATP2A2 BCL2L1 CDKL1 CRK CUL4A EDEM1 EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 LAMP1 MPL MPO MTDH NEDD4 NRAS NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PROZ PTPN11 PTPN6 PTPRF PTPRR RAP2A RPTOR SHC1 SLC35B1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ	3 interacting genes: F2 IRS2 TUBGCP3
Entrez ID		8660	8858
HPRD ID		02878	07182
Ensembl ID		ENSG00000185950	ENSG00000126231
Uniprot IDs		Q9P084 Q9Y4H2	P22891
PDB IDs		3FQW 3FQX	3F1S 3H5C
Enriched GO Terms of Interacting Partners?
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