NCOA1 and NR3C1

Number of citations of the paper that reports this interaction (PubMedID 12917342)
70

Data Source:
HPRD (in vitro, two hybrid)

		NCOA1	NR3C1
Description		nuclear receptor coactivator 1	nuclear receptor subfamily 3 group C member 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane Protein-containing Complex Neuron Projection	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Microtubule Organizing Center Spindle Cytosol Nuclear Speck Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Aryl Hydrocarbon Receptor Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Progesterone Receptor Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein Dimerization Activity Protein N-terminus Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Nuclear Receptor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Hsp90 Protein Binding Steroid Hormone Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Regulation Of Thyroid Hormone Mediated Signaling Pathway Lactation Male Gonad Development Cerebellum Development Hippocampus Development Hypothalamus Development Cerebral Cortex Development Response To Estradiol Response To Retinoic Acid Response To Progesterone Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Histone H4 Acetylation Estrous Cycle Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Male Mating Behavior Labyrinthine Layer Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cellular Response To Drug	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Cycle Chromosome Segregation Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Division Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Circadian Clock SUMOylation of intracellular receptors PTK6 Expression Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS
Drugs		Genistein Corticosterone Prinaberel ERB-196 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL TO-901317 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE GW-590735 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 3,20-Pregnanedione Indeglitazar (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myristic acid 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Aleglitazar	Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol acetate Levonorgestrel Beclomethasone dipropionate Progesterone Spironolactone Betamethasone Desoximetasone Fluticasone propionate Fluocinolone acetonide Ulobetasol Triamcinolone Prednisone Flumethasone Fludrocortisone Norethisterone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol etabonate Rimexolone Methylprednisolone Clobetasol propionate Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Drospirenone Ciclesonide Hexane-1,6-Diol Aldosterone ORG-34517 Difluprednate Ulipristal Fluticasone furoate Tixocortol Difluocortolone Gestrinone Deflazacort Onapristone Cortivazol Clobetasone Fluticasone Mometasone furoate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Segesterone acetate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate Prednisolone acetate
Diseases
GWAS		Asthma ( 29273806) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Breast cancer ( 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chromium levels ( 26025379) Cognitive function ( 28093568) Diffuse large B cell lymphoma ( 25261932) Hand grip strength ( 29691431) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Atrial fibrillation ( 30061737 29892015) Hip circumference adjusted for BMI ( 34021172) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Spatial processing ( 31596458)
Interacting Genes		90 interacting genes: AHR ANKRD11 AR ARID1A ARNT BCL3 CARM1 CCND1 CHMP2A CIITA COPS5 CPS1 CREBBP CXADR CYB561 DDX17 DDX5 EP300 ESR1 ESR2 ESRRA ESRRG FOS FOXA2 FOXO1 GTF2B HADHA HIF1A HNF1A HNF4A HNF4G JUN KANK2 KAT2B MAPK1 NCOR1 NFKB1 NKX2-1 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR5A1 NR5A2 NR6A1 PAGR1 PGR PPARA PPARD PPARG PPARGC1A PPM1B PPP1CB PRMT1 PRMT2 PSMB9 RARA RARB RARG RORA RORB RXRA RXRB SLC28A2 SMARCC1 SMARCE1 SNW1 SRD5A2 SRF STAT3 STAT6 SUMO1 TBP TEAD1 TEAD2 THRA THRB TP53 TRIM27 TRIP4 VDR YWHAH YWHAQ ZNF512	163 interacting genes: ABCC1 ADA AR ARPC5 BAG1 C1orf94 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAPK1 DCAF6 DDX54 DNMT3L DOCK3 DTD1 ECD EFHC2 EGFR EP300 EPB41L1 ETS1 ETS2 FAM161B FKBP4 FTH1 FYN GNB1 GNB2 GRIP1 H3C1 HDAC1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSP90AB1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 KRTCAP3 LCK LPXN LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR0B2 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 NUP54 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRDX3 PRKACA PRKDC PRPF6 PSMC3IP PTEN PTGES3 PTMS RACK1 RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RFPL2 RNF14 RXRB SFN SGTA SHKBP1 SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SPIN2A SRA1 SRC STAT3 STAT5A STAT5B STRN3 STUB1 SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TNS4 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 UBR1 WTIP YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496
Entrez ID		8648	2908
HPRD ID		04070	00679
Ensembl ID		ENSG00000084676	ENSG00000113580
Uniprot IDs		Q15788	B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150
PDB IDs		1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE 1ZAF 2A3I 2C52 2FVJ 2GTK 2HBH 2HC4 2HCD 2HFP 2NPA 2NV7 2P54 2PRG 3BEJ 3BQD 3CTB 3CWD 3DCT 3DCU 3DR1 3ET1 3ET3 3FEI 3FEJ 3FUR 3FXV 3G8I 3G9E 3GYT 3GYU 3H0A 3HC5 3HC6 3HVL 3IPQ 3IPS 3IPU 3KMR 3LMP 3OKH 3OKI 3OLF 3OLL 3OLS 3OMK 3OMM 3OMO 3OMP 3OMQ 3OOF 3OOK 3P88 3P89 3QT0 3RUT 3RUU 3RVF 3S9S 3T03 3UU7 3UUA 3UUD 3V9Y 3VN2 4DK7 4DK8 4DM6 4DM8 4DQM 4F9M 4FGY 4G1D 4G1Y 4G1Z 4G20 4G21 4G2H 4HEE 4J5X 4JYG 4JYH 4JYI 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGC 4MGD 4RUJ 4RUP 4TUZ 4TV1 4UDA 4UDB 4Y29 5A86 5AVI 5AVL 5AZT 5DSH 5DV3 5DV6 5DV8 5DVC 5DWL 5E7V 5GTN 5GTO 5GTP 5HJS 5JI0 5JMM 5L7E 5L7G 5L7H 5MWP 5MWY 5MX7 5NKY 5NMA 5NMB 5NWM 5OW7 5OW9 5OWD 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5X0R 5X8U 5X8W 5Y44 5YCN 5YCP 5YP6 6A5W 6A5X 6A5Y 6A5Z 6A60 6BNS 6E3G 6FO7 6FO8 6FO9 6FOB 6FOD 6GEV 6GG8 6HTY 6ICJ 6IJR 6IJS 6ILQ 6ITM 6JNR 6JQ7 6KTM 6KTN 6L96 6NX1 6P9F 6SSQ 6T2M 6TFI 6U25 6W9H 6W9I 6XP9 7BPY 7BPZ 7BQ0 7BQ1 7BQ2 7BQ3 7BQ4 7JYM 7KXD 7KXE 7KXF	1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X 4UDC 4UDD 5CBX 5CBY 5CBZ 5CC1 5E69 5E6A 5E6B 5E6C 5E6D 5EMC 5EMP 5EMQ 5G3J 5G5W 5NFP 5NFT 5UC3 5VA0 5VA7 6BQU 6CFN 6DXK 6EL6 6EL7 6EL9
Enriched GO Terms of Interacting Partners?
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