AKR1C3 and ACIN1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		AKR1C3	ACIN1
Description		aldo-keto reductase family 1 member C3	apoptotic chromatin condensation inducer 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck ASAP Complex
	Molecular Function	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity NAD-retinol Dehydrogenase Activity Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Bile Acid Binding Dihydrotestosterone 17-beta-dehydrogenase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin D2 11-ketoreductase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin-F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Delta4-3-oxosteroid 5beta-reductase Activity D-threo-aldose 1-dehydrogenase Activity NADP-retinol Dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Nucleic Acid Binding RNA Binding Protein Binding ATP Hydrolysis Activity Enzyme Binding
	Biological Process	Retinoid Metabolic Process Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Male Gonad Development Cellular Response To Starvation Positive Regulation Of Cell Death Farnesol Catabolic Process Cyclooxygenase Pathway Keratinocyte Differentiation Cellular Response To Reactive Oxygen Species Progesterone Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Macromolecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Testosterone Biosynthetic Process Renal Absorption Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	MRNA Processing RNA Splicing Erythrocyte Differentiation Apoptotic Chromosome Condensation Positive Regulation Of Monocyte Differentiation
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of Prostaglandins (PG) and Thromboxanes (TX) RA biosynthesis pathway Retinoid metabolism and transport	Apoptotic cleavage of cellular proteins
Drugs		NADH Indomethacin Androstenedione Rutin Prostaglandin D2 Flufenamic acid Nicotinamide adenine dinucleotide phosphate 3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran
Diseases
GWAS		Epithelial ovarian cancer ( 31469419) Homeostasis model assessment of insulin resistance ( 33381925)
Interacting Genes		7 interacting genes: ACIN1 IL2RA LRIF1 MAGEA11 SIAH2 UBE2W ZHX1	12 interacting genes: ABCF3 AKR1C3 BTBD10 CASP3 CSNK2A1 KLHL26 LINC01554 PAFAH1B2 PCBD1 SRPK2 SUMO2 YWHAG
Entrez ID		8644	22985
HPRD ID		04911	05191
Ensembl ID		ENSG00000196139	ENSG00000100813
Uniprot IDs		A0A0A0MSS8 B4DKT3 P42330	B4DQZ7 Q9UKV3
PDB IDs		1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C 4HMN 4WDT 4WDU 4WDW 4WDX 4WRH 4XVD 4XVE 4YVV 4YVX 4ZFC 5HNT 5HNU 6A7B 6F2U 6F78 6GXK 7C7F 7C7G 7C7H	6G6S
Enriched GO Terms of Interacting Partners?
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