PDE8B and BBS7

		PDE8B	BBS7
Description		phosphodiesterase 8B	Bardet-Biedl syndrome 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Photoreceptor Outer Segment Nucleus Centrosome Cytosol Axoneme Membrane BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	CAMP Catabolic Process Signal Transduction	Eye Development Heart Looping Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Brain Development Visual Perception Protein Localization Protein Transport Melanosome Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Intracellular Transport Digestive Tract Morphogenesis Pigment Granule Aggregation In Cell Center Limb Development Cilium Assembly Primary Palate Development Non-motile Cilium Assembly
Pathways		G alpha (s) signalling events	BBSome-mediated cargo-targeting to cilium
Drugs		Caffeine Trapidil
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Caudate nucleus volume ( 21502949) Chronotype ( 30696823) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965 22493691) Medication use (thyroid preparations) ( 31015401) Serum thyroid-stimulating hormone levels ( 25436638) SjÃ¶gren's syndrome ( 28076899) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335 18514160)	Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Psoriasis ( 31376382)
Interacting Genes		2 interacting genes: BBS7 SSBP2	12 interacting genes: ANXA5 CNGA1 FHOD1 JUN KRT18 MAD2L1 MSH6 NDNF PAX2 PDE8B QRFPR TRPC3
Entrez ID		8622	55212
HPRD ID		04546	07399
Ensembl ID		ENSG00000113231	ENSG00000138686
Uniprot IDs		B3KN77 O95263	Q8IWZ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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