PRKRA and ZMAT4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRKRA	ZMAT4
Description		protein activator of interferon induced protein kinase EIF2AK2	zinc finger matrin-type 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Skeletal System Morphogenesis Regulation Of Catalytic Activity Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Body fat mass ( 28552196) Brain volume in infants (grey matter) ( 28763065) Coffee consumption ( 31046077) Fasting plasma glucose ( 17903298) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Hip circumference ( 28552196) Iris color (L* coordinate) ( 30895295) Lung cancer ( 28604730) Myopia ( 27182965) Pediatric areal bone mineral density (concordant skeletal phenotype) ( 29240982) Refractive error ( 23396134 32231278) Severe aplastic anemia ( 32004448) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference ( 28552196)
Interacting Genes		34 interacting genes: ADARB1 AGO2 CAT CEBPZ CEP126 CLASP1 COPS6 DICER1 EHHADH EIF2AK2 FZD7 GDF9 HEYL LNX1 LYAR NKRF PIAS2 PITPNM1 PLEKHA3 POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 STAU1 STRBP TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZMAT4 ZNF746	11 interacting genes: ADARB1 APP CUL3 CUL4B DAPK1 LRSAM1 PRKRA SRPK2 STRBP TARBP2 THAP1
Entrez ID		8575	79698
HPRD ID		04573	07837
Ensembl ID		ENSG00000180228	ENSG00000165061
Uniprot IDs		A0A7I2V2I8 B4DJC7 O75569	Q9H898
PDB IDs		2DIX
Enriched GO Terms of Interacting Partners?
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