CAV1 and TNFRSF1B

Number of citations of the paper that reports this interaction (PubMedID 11112773)
38

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CAV1	TNFRSF1B
Description		caveolin 1	TNF receptor superfamily member 1B
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Nucleus Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Neuronal Cell Body Varicosity Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Patched Binding Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Protein Heterodimerization Activity Nitric-oxide Synthase Binding ATPase Binding Molecular Adaptor Activity Inward Rectifier Potassium Channel Inhibitor Activity	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Protein Localization Response To Bacterium Positive Regulation Of Calcium Ion Transport Into Cytosol Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Positive Regulation Of Peptidase Activity Protein Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Fatty Acid Metabolic Process Lipid Storage Cell Differentiation Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Insulin Receptor Internalization Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Response To Estrogen Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Pinocytosis Negative Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Necroptotic Process Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Exogenous DsRNA Cellular Response To Peptide Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Transforming Growth Factor Beta Stimulus Basement Membrane Organization Caveolin-mediated Endocytosis Regulation Of Heart Rate By Cardiac Conduction Angiotensin-activated Signaling Pathway Involved In Heart Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Cold-induced Thermogenesis Regulation Of Ruffle Assembly Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Localization To Basolateral Plasma Membrane Positive Regulation Of Gap Junction Assembly Negative Regulation Of Inward Rectifier Potassium Channel Activity Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Inflammatory Response Immune Response Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of RNA Biosynthetic Process
Pathways		Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle FOXO-mediated transcription of cell cycle genes RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Tasonermin
Diseases
GWAS		Atrial fibrillation ( 28416822 30061737 29892015 22544366) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673 29891935 25173105 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 29617998 25173106 28073927 29235454) Ischemic stroke (cardioembolic) ( 29531354) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) P wave duration ( 28794112) Platelet distribution width ( 32888494) PR interval ( 30679814 29127183 30046033 32439900 20062060 25035420 23139255) PR segment duration ( 24850809) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QRS duration ( 30012220) QT interval ( 24952745 29874175) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Asthma ( 31959851) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		86 interacting genes: ABCB1 ABL1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DANCR DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FOXP2 FYN GJA1 GJA3 GJB2 GLP1R GNAI2 GRB7 GRK1 GRK2 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KCNA3 KDR LRP1 MALL MAPK1 MAPK3 MET MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TEK TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VAV2	22 interacting genes: ADAM17 BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 HIVEP3 ICAM3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420
Entrez ID		857	7133
HPRD ID		03028	01862
Ensembl ID		ENSG00000105974	ENSG00000028137
Uniprot IDs		A0A024R757 A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3	P20333
PDB IDs			1CA9 3ALQ
Enriched GO Terms of Interacting Partners?
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