CDK10 and ETS2

Number of citations of the paper that reports this interaction (PubMedID 11313931)
31

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CDK10	ETS2
Description		cyclin dependent kinase 10	ETS proto-oncogene 2, transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ciliary Basal Body	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Peptidyl-threonine Phosphorylation Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Negative Regulation Of Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation
Pathways			Oncogene Induced Senescence
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Height ( 25429064) Hemoglobin levels ( 32327693) Intake of total sugars ( 31005972) Melanoma ( 28212542) Red vs. brown/black hair color ( 30531825) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) Central corneal thickness ( 32528159) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) TPE interval (response to exercise) ( 32386560)
Interacting Genes		4 interacting genes: CCR4 ETS2 FBXO7 RNF115	22 interacting genes: CDK10 COP1 CREBBP EP300 ERG ETS1 FOS GATA3 HMGN1 JUN MFSD14B NCOR1 NR3C1 POU5F1 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11
Entrez ID		8558	2114
HPRD ID		04588	01263
Ensembl ID		ENSG00000185324	ENSG00000157557
Uniprot IDs		B7Z537 Q15131	P15036
PDB IDs			4BQA 4MHV
Enriched GO Terms of Interacting Partners?
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