TCAP and TTN

Number of citations of the paper that reports this interaction (PubMedID 9804419)
79

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		TCAP	TTN
Description		titin-cap	titin
Image
GO Annotations	Cellular Component	Cytosol Z Disc I Band	Condensed Nuclear Chromosome Extracellular Region Cytosol Z Disc I Band Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Titin Z Domain Binding	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity Protein Serine Kinase Activity
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Cardiac Muscle Hypertrophy In Response To Stress Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly	Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Peptidyl-tyrosine Phosphorylation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Sarcomerogenesis Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Platelet degranulation Striated Muscle Contraction
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)	Atrial fibrillation ( 29290336 30061737 29892015) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Left ventricular ejection fraction ( 33495596 32382064) Left ventricular end-diastolic volume ( 33495596 32382064) Left ventricular end-systolic volume ( 33495596 32382064) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass ( 33495596) PR interval ( 30046033 32439900) QT interval ( 20031603 29213071 24952745 29874175) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Resting heart rate ( 27798624) Sick sinus syndrome ( 33580673) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		39 interacting genes: ADPGK ANKRD2 ASB6 ATXN1 BLZF1 C19orf54 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPA8 HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN	77 interacting genes: ABLIM1 ABLIM2 ACTA1 ACTN1 ACTN2 ACTN3 ACTN4 AMOT ANK1 ANKRD1 ANKRD2 ANKRD23 ANKRD28 ASH2L ATP5F1D C1QTNF9 CALM1 CAPN3 CCT6A CHD4 CLIP4 CRYAB DNAJB5 DNAJB6 DUSP6 ENO1 ENO3 EXOSC10 FHL1 FHL2 FLNA FN1 FNDC3B GABARAP HSPA1B HSPB2 ITGB1BP2 ITGB5 JPH1 LIMS1 MAPK1 MAST2 MYBPC1 MYBPC2 MYBPC3 MYBPH MYCBP2 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB NEK9 NEO1 OBSCN PARD3 PHGDH POMP PYGM RNF167 RPL12 RYR1 SF1 SGCG SH3GLB1 SQSTM1 SRPK2 TAB2 TCAP TRIM55 TRIM63 TSC22D2 TTC3 UBE2I UGP2 VAV2
Entrez ID		8557	7273
HPRD ID		05133	01787
Ensembl ID		ENSG00000173991	ENSG00000155657
Uniprot IDs		A2TDC0 O15273	A0A0A0MRA3 A0A0A0MTS7 Q7Z3B7 Q8WZ42
PDB IDs		1YA5 2F8V	1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6H4L 6HCI 6I0Y 6SDB 7NIP
Enriched GO Terms of Interacting Partners?
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