RHPN2 and RHOB

Number of citations of the paper that reports this interaction (PubMedID 12473120)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RHPN2	RHOB
Description		rhophilin Rho GTPase binding protein 2	ras homolog family member B
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Extracellular Exosome
	Molecular Function		GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Glomerular Filtration Signal Transduction Negative Regulation Of Stress Fiber Assembly	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle	GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle
Drugs			Botulinum toxin type A
Diseases
GWAS		Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 30529582 19011631 24836286 24737748 31826910) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Macular thickness ( 30535121) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Serum alkaline phosphatase levels ( 33547301)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		6 interacting genes: KRT18 RARG RHOA RHOB SMURF1 TGFBR1	14 interacting genes: ADORA2A ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 SNX17 TNFAIP1
Entrez ID		85415	388
HPRD ID		10192	01321
Ensembl ID		ENSG00000131941	ENSG00000143878
Uniprot IDs		Q8IUC4	P62745
PDB IDs		2VSV	2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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