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IKBKG and POLR2D
Number of citations of the paper that reports this interaction (PubMedID
20211142
)
361
Data Source:
BioGRID
(two hybrid)
IKBKG
POLR2D
Description
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
RNA polymerase II subunit D
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
P-body
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Cytosol
Nuclear Speck
Molecular Function
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Nucleotide Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Translation Initiation Factor Binding
Biological Process
Apoptotic Process
Inflammatory Response
Immune Response
Cellular Response To DNA Damage Stimulus
I-kappaB Kinase/NF-kappaB Signaling
Response To Virus
Positive Regulation Of Macroautophagy
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Negative Regulation Of Neuron Death
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
MRNA Export From Nucleus In Response To Heat Stress
Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex
Positive Regulation Of Translational Initiation
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
AGRO100
Tarenflurbil
Diseases
GWAS
Hemoglobin levels (
26366553
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Interacting Genes
245 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BIRC3
BRME1
C19orf12
CALB1
CALCOCO2
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IFIT5
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAPRE1
MARCHF2
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKDC
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RELA
RET
RHOA
RIPK1
RIPK2
RNF11
RNF31
RNF34
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP10
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
16 interacting genes:
ATF7IP
EMX1
ESR1
HOXC9
IKBKG
NR5A2
POLR2A
POLR2B
POLR2C
POLR2E
POLR2G
POLR2H
POLR2K
POLR2L
TRIM29
ZSCAN1
Entrez ID
8517
5433
HPRD ID
02217
16191
Ensembl ID
ENSG00000269335
ENSG00000144231
Uniprot IDs
A0A087X1B1
Q9Y6K9
O15514
PDB IDs
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
2C35
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
Enriched GO Terms of Interacting Partners
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