ORAI1 and TRPC3

Number of citations of the paper that reports this interaction (PubMedID 17360584)
124

Data Source:
HPRD (in vivo, in vitro)

		ORAI1	TRPC3
Description		ORAI calcium release-activated calcium modulator 1	transient receptor potential cation channel subfamily C member 3
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Calcium Channel Complex Plasma Membrane Raft Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex
	Molecular Function	Calcium Channel Activity Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Store-operated Calcium Entry Adaptive Immune Response Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Mammary Gland Epithelium Development Calcium Ion Import Calcium Ion Transmembrane Transport	Calcium Ion Transport Manganese Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels
Drugs
Diseases
GWAS		Experiencing mood swings ( 29500382) Major depressive disorder ( 27777418)	Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		2 interacting genes: TRPC3 TRPC6	21 interacting genes: BBS7 CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		84876	7222
HPRD ID		08599	15999
Ensembl ID			ENSG00000138741
Uniprot IDs		A0A024RBT3 Q96D31	Q13507
PDB IDs		2MAK 4EHQ	5ZBG 6CUD 6D7L 6DJS
Enriched GO Terms of Interacting Partners?
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