PRRC2B and EHMT2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		PRRC2B	EHMT2
Description		proline rich coiled-coil 2B	euchromatic histone lysine methyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication DNA Methylation Synaptonemal Complex Assembly Spermatid Development Long-term Memory Cellular Response To Starvation Fertilization DNA Methylation On Cytosine Within A CG Sequence Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Organ Growth Phenotypic Switching Regulation Of DNA Methylation Response To Ethanol Behavioral Response To Cocaine Neuron Fate Specification Histone H3-K9 Methylation Regulation Of Histone H3-K4 Methylation Regulation Of Histone H3-K9 Methylation Response To Fungicide Histone H3-K27 Methylation Cellular Response To Cocaine Cellular Response To Xenobiotic Stimulus Negative Regulation Of Autophagosome Assembly
Pathways			Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Lung function ( 31902109) Urate levels ( 31578528)	Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body shape index ( 34021172) Chronic hepatitis B infection ( 25802187 23760081) Chronotype ( 30696823) Clostridioides difficle infection ( 33841421) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: AK8 APP ATN1 ATXN1 ATXN1L CFAP77 CRK DDX31 DNAJC5 DPY30 EHMT2 FBXO7 GTF3C4 PLPP7 RERE SETX SRPK2 UCK1	61 interacting genes: ABHD17A ANKRD28 ATF7IP AURKA BBS9 CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 EIF4A3 EPDR1 ESR1 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS HIC2 ITGB5 KLF12 KLF3 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MX2 NAA10 NAA11 NAPRT PLOD3 POR PRRC2B PSMA1 PTGER4 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 VEZF1 WIZ XAGE2 ZBTB38 ZNF446 ZNF462 ZNF512B ZNF688 ZNF775 ZNF785 ZNF837
Entrez ID		84726	10919
HPRD ID		13805	06854
Ensembl ID		ENSG00000288701	ENSG00000204371
Uniprot IDs		Q5JSZ5 Q9BU62	A0A024RCN9 A2ABF8 B7Z852 Q59FM7 Q96KQ7
PDB IDs			2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1 7BTV 7BUC 7DCF
Enriched GO Terms of Interacting Partners?
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