SORBS2 and SYNJ1

Number of citations of the paper that reports this interaction (PubMedID 11292345)
20

Data Source:
HPRD (in vitro)

		SORBS2	SYNJ1
Description		sorbin and SH3 domain containing 2	synaptojanin 1
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Z Disc Lamellipodium Perinuclear Region Of Cytoplasm	Cytosol Microtubule Vesicle Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Parallel Fiber To Purkinje Cell Synapse Presynapse
	Molecular Function	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle	RNA Binding Phosphatidylinositol-3-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein C-terminus Binding SH3 Domain Binding Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Protein-containing Complex Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity EH Domain Binding
	Biological Process	Actin Filament Organization Notch Signaling Pathway Biological_process Cell Growth Involved In Cardiac Muscle Cell Development	Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Brain Development Learning Positive Regulation Of Gliogenesis Synaptic Vesicle Priming Synaptic Vesicle Uncoating Response To Retinoic Acid Response To Cytokine Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Short-term memory (digit-span task) ( 30741946) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		47 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 DYNC1H1 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SHANK3 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ	25 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2 VPS26C
Entrez ID		8470	8867
HPRD ID		12473	09182
Ensembl ID		ENSG00000154556	ENSG00000159082
Uniprot IDs		B7Z3D7 B7Z997 O94875	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs		5VEI	1W80 2DNR 2VJ0 7A0V
Enriched GO Terms of Interacting Partners?
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