TPST1 and CMKLR1

Number of citations of the paper that reports this interaction (PubMedID 17558413)
25

Data Source:
HPRD (in vitro)

		TPST1	CMKLR1
Description		tyrosylprotein sulfotransferase 1	chemerin chemokine-like receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Golgi Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity	Complement Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Signaling Receptor Activity Adipokinetic Hormone Receptor Activity Adipokinetic Hormone Binding
	Biological Process	Peptidyl-tyrosine Sulfation Inflammatory Response 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Skeletal System Development Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fat Cell Differentiation Regulation Of Calcium-mediated Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699	Class A/1 (Rhodopsin-like receptors)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Gout ( 22179738)	Acne (severe) ( 24927181) Bipolar disorder ( 22688191) Erectile dysfunction and prostate cancer treatment ( 20932654) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Protein level change in low calorie diet obesity intervention ( 29234017) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 21483023) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		6 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GP1BA SELPLG	2 interacting genes: TPST1 TPST2
Entrez ID		8460	1240
HPRD ID		07216	03829
Ensembl ID		ENSG00000169902	ENSG00000174600
Uniprot IDs		A0A024RDK9 O60507	Q99788
PDB IDs		5WRI 5WRJ
Enriched GO Terms of Interacting Partners?
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