MCM8 and FEM1C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MCM8	FEM1C
Description		minichromosome maintenance 8 homologous recombination repair factor	fem-1 homolog C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol MCM Complex MCM8-MCM9 Complex	Ubiquitin Ligase Complex Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication Cellular Response To DNA Damage Stimulus Cell Cycle Female Gamete Generation DNA Duplex Unwinding Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Protein Localization To Chromatin	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Neddylation
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Estradiol levels ( 34255042) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)	Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		4 interacting genes: FEM1C MCM4 MCM6 MCM7	8 interacting genes: BCL2L11 CEP63 DCP2 LZTS2 MALT1 MCM8 PNMA1 RPGRIP1
Entrez ID		84515	56929
HPRD ID		12186	16384
Ensembl ID		ENSG00000125885	ENSG00000145780
Uniprot IDs		B4DN82 Q9UJA3	Q96JP0
PDB IDs		6L0O	6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA
Enriched GO Terms of Interacting Partners?
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