PCGF6 and KDM5D

Number of citations of the paper that reports this interaction (PubMedID 17320162)
110

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		PCGF6	KDM5D
Description		polycomb group ring finger 6	lysine demethylase 5D
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Protein Binding Metal Ion Binding	DNA Binding Protein Binding Histone Demethylase Activity Histone H3-methyl-lysine-4 Demethylase Activity Histone H3-tri/di/monomethyl-lysine-4 Demethylase Activity Metal Ion Binding Androgen Receptor Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated	T Cell Antigen Processing And Presentation Chromatin Remodeling Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Regulation Of Androgen Receptor Signaling Pathway
Pathways		Transcriptional Regulation by E2F6	HDMs demethylate histones
Drugs			Ascorbic acid
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)	Autism ( 32996047)
Interacting Genes		27 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 OGT PEX10 PNMA1 RAD18 RING1 RNF2 SS18L1 TRIM14 TRIM55 TRIM63 TULP3 UBE2D3 UBE2U USP2 USP21	2 interacting genes: H3-4 PCGF6
Entrez ID		84108	8284
HPRD ID		07427	02464
Ensembl ID		ENSG00000156374	ENSG00000012817
Uniprot IDs		Q9BYE7	A0A384MR42 Q9BY66
PDB IDs		2DJB	2E6R 2YQE
Enriched GO Terms of Interacting Partners?
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