PIP4K2B and CDCA7L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PIP4K2B	CDCA7L
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 beta	cell division cycle associated 7 like
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding ATP Binding GTP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity	Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Autophagosome-lysosome Fusion Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs		Fostamatinib
Diseases
GWAS		Height ( 28552196 20881960 31562340)	Breast cancer ( 29059683) Gamma glutamyl transferase levels ( 33339817) Height ( 20189936) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Pre-treatment viral load in HIV-1 infection ( 31219150) Squamous cell lung carcinoma ( 28604730) Urate levels in obese individuals ( 25811787)
Interacting Genes		17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131	68 interacting genes: ABT1 ANKRD1 ANKRD11 ANKRD23 AVPI1 AXIN1 BAG5 BEND7 BHLHB9 BRPF1 BYSL CARD9 CAVIN1 CCDC116 CCDC33 CEP70 CTNNBL1 DAXX DEDD2 DMAP1 EIF4A3 FAM217B FAM9B GOLGA2 HSF2BP ING5 JADE2 KRTAP10-7 LMO1 MCRS1 MDFI MEOX2 MFAP1 MLH1 MORN3 MRPL28 MYC NDUFB7 NOL12 NOP2 PBX1 PBX2 PICK1 PIH1D1 PIP4K2B PPP1R16A PPP1R16B PRDM14 PRPF31 RRP7A SNRNP48 SSX1 SSX2IP STX11 SUV39H1 TADA2A TFPT TNNI1 TRAF3IP3 TRIM42 UBL4A UTP3 VDR ZGPAT ZNF250 ZNF438 ZNF620 ZNF821
Entrez ID		8396	55536
HPRD ID		04463	11481
Ensembl ID		ENSG00000276293	ENSG00000164649
Uniprot IDs		P78356	A0A024RA51 A8K8X5 Q96GN5
PDB IDs		1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H	5YI9 6EMO
Enriched GO Terms of Interacting Partners?
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