TSSK1B and TGFBR2

Number of citations of the paper that reports this interaction (PubMedID 15761153)
269

Data Source:
HPRD (in vivo)

		TSSK1B	TGFBR2
Description		testis specific serine kinase 1B	transforming growth factor beta receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Motile Cilium	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Membrane Raft
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Activin-activated Receptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Protein Phosphorylation Spermatid Development Intracellular Signal Transduction	Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia In Utero Embryonic Development Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Tricuspid Valve Morphogenesis Cardiac Left Ventricle Morphogenesis Endocardial Cushion Fusion Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Notch Signaling Pathway Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Animal Organ Regeneration Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Embryonic Hemopoiesis Wound Healing Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Response To Steroid Hormone Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Secondary Palate Development Response To Cholesterol Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Proliferation Involved In Endocardial Cushion Morphogenesis Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Lens Fiber Cell Apoptotic Process MiRNA Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways			Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases
Drugs		Fostamatinib	Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Fostamatinib
Diseases
GWAS			Breast cancer ( 29059683 23535729) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cognitive decline rate in late mild cognitive impairment ( 26252872) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Migraine ( 22683712 27322543) Migraine - clinic-based ( 23793025) Night sleep phenotypes ( 27126917) Postprandial triglyceride response ( 32603185) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systolic blood pressure ( 30224653) Tonometry ( 17903302)
Interacting Genes		8 interacting genes: CHEK2 EFS FAM229B FOXN1 MEOX2 TGFBR1 TGFBR2 TSKS	50 interacting genes: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX DYNLT4 EIF3I ENG FANCC GOPC KCNK18 MAP2K1 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML PPP2CB PSMD14 RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TDGF1 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TRMO TSSK1B ZFYVE9 ZNF510
Entrez ID		83942	7048
HPRD ID		11610	01823
Ensembl ID		ENSG00000212122	ENSG00000163513
Uniprot IDs		A0ZT98 Q9BXA7	A3QNQ0 D2JYI1 P37173
PDB IDs			1KTZ 1M9Z 1PLO 2PJY 3KFD 4P7U 4XJJ 5E8V 5E8Y 5E91 5E92 5QIN 5TX4 5TY4
Enriched GO Terms of Interacting Partners?
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