STK40 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		STK40	POLA2
Description		serine/threonine kinase 40	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Protein Binding ATP Binding Protein Serine Kinase Activity	Molecular_function DNA Binding Protein Binding
	Biological Process	Respiratory System Process Glycogen Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Lung Alveolus Development Lung Morphogenesis	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs			Dacarbazine
Diseases
GWAS		Neutrophil count ( 32888494)	Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		8 interacting genes: APP COP1 COPS6 LRRK2 NEDD4L POLA2 SLIRP SNIP1	41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2
Entrez ID		83931	23649
HPRD ID		11359	10160
Ensembl ID		ENSG00000196182	ENSG00000014138
Uniprot IDs		Q8N2I9	Q14181
PDB IDs		5L2Q	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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