RSPH3 and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RSPH3	PRKAR1A
Description		radial spoke head 3	protein kinase cAMP-dependent type I regulatory subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Sperm Connecting Piece Ciliary Base Glutamatergic Synapse
	Molecular Function	Protein Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process		Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases
GWAS		Attention deficit hyperactivity disorder ( 32279069) Bladder cancer (smoking interaction) ( 24662972) Celiac disease ( 25920553) Lipoprotein (a) levels ( 26377243) Prepulse inhibition of the startle response ( 31596458) Systemic lupus erythematosus ( 28714469)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		9 interacting genes: APP DPY30 FAM124B HSPB1 MLH1 PRKAR1A ROPN1L RSPH14 TAGAP	47 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP5 AKAP7 ARFGEF2 BAHD1 C11orf49 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		83861	5573
HPRD ID		15279	01786
Ensembl ID		ENSG00000130363	ENSG00000108946
Uniprot IDs		Q86UC2	B2R5T5 P10644
PDB IDs			5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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