CAPN2 and PBXIP1

Number of citations of the paper that reports this interaction (PubMedID 25486428)
11

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CAPN2	PBXIP1
Description		calpain 2	PBX homeobox interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrial Intermembrane Space Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum	Chromatin Nucleus Transcription Regulator Complex Cytosol Microtubule Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Enzyme Binding Protein-containing Complex Binding	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Activity Protein Binding
	Biological Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Autoprocessing Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Positive Regulation Of Neuron Death Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process	Production Of Molecular Mediator Involved In Inflammatory Response Cell Adhesion Multicellular Organism Development Cell Migration Extracellular Matrix Disassembly Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Articular Cartilage Development Histone H3-K56 Acetylation Gene Expression Involved In Extracellular Matrix Organization Positive Regulation Of Chondrocyte Proliferation Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Waist circumference ( 31170924)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)
Interacting Genes		24 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KNG1 MAPK1 MAPT MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 TUBA4A ZFYVE21	28 interacting genes: BRPF1 CAMLG CAPN2 CCDC85B CCNC DAXX DEF6 DPPA2 ESR1 GABARAPL1 GMCL1 GRB2 KRTAP10-6 LCA5L MDFI MDM2 MORF4L1 PCBD2 PPTC7 PRKAA2 SGTA TRAF7 TSNAX UBQLN1 UBQLN4 WASHC3 ZMYND8 ZZZ3
Entrez ID		824	57326
HPRD ID		00254	17823
Ensembl ID		ENSG00000162909	ENSG00000163346
Uniprot IDs		B4DN77 P17655 Q59EF6	B4E0K4 Q96AQ6
PDB IDs		1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?
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